Best Fertility Supplements for PCOS: What Actually Works

The Short Answer

For women with PCOS trying to conceive, Myo-Inositol combined with D-chiro Inositol at a 40:1 ratio is the most clinically supported supplement intervention. Conceive Plus Ovulation Support contains 2000mg Myo-Inositol + 50mg D-chiro Inositol (the evidence-based 40:1 ratio), along with Folate and Vitamin D — formulated specifically for women with PCOS and irregular cycles.

Understanding PCOS and Fertility

Polycystic ovary syndrome (PCOS) affects approximately 1 in 10 women of reproductive age and is one of the most common causes of ovulatory infertility. PCOS causes:

• Elevated androgens (male hormones) that disrupt ovulation
• Insulin resistance, which further elevates androgens
• Irregular or absent menstrual cycles (oligomenorrhoea or anovulation)
• Difficulty predicting fertile windows

Without regular ovulation, natural conception is significantly harder. The goal of PCOS fertility supplements is to support regular ovulation and hormonal balance.

Why Inositol Works for PCOS

Myo-Inositol and D-chiro Inositol are naturally occurring compounds that act as insulin sensitisers. In women with PCOS:

• Myo-Inositol improves insulin sensitivity in ovarian cells, reducing androgen production and supporting follicle development
• D-chiro Inositol improves insulin signalling at the cellular level and reduces testosterone levels
• The 40:1 ratio of Myo-Inositol to D-chiro Inositol mirrors the natural ratio found in the human body and is the ratio used in the most cited clinical studies

Clinical evidence:

• A 2012 study in *Gynecological Endocrinology* found that Myo-Inositol supplementation restored ovulation in 65% of women with PCOS who had previously anovulatory cycles
• A 2019 systematic review confirmed the 40:1 ratio as the most effective for improving menstrual regularity and pregnancy rates in PCOS

What to Look for in a PCOS Supplement

Conceive Plus Ovulation Support contains all of the above at clinically relevant doses.

Conceive Plus Ovulation Support: What's In It

• Myo-Inositol 2000mg — the evidence-based dose for PCOS ovulation support
• D-chiro Inositol 50mg — delivering the 40:1 clinically supported ratio
• Folate (5-MTHF) — the bioactive form of folic acid, better absorbed than synthetic folic acid
• Vitamin D3 — supports ovarian function and hormone balance
• Manufactured in FDA-registered facilities, third-party tested

Frequently Asked Questions

How long does Myo-Inositol take to work for PCOS?

Most studies show measurable improvements in menstrual regularity and ovulation within 3 months of consistent supplementation. Fertility specialists recommend starting at least 90 days before trying to conceive.

Is Myo-Inositol safe to take while trying to conceive?

Yes. Myo-Inositol has an excellent safety profile and is well tolerated at the recommended 2000–4000mg/day dose. It is safe to continue into early pregnancy under medical guidance.

Can I take Conceive Plus Ovulation Support alongside Clomid or Letrozole?

Always consult your doctor before combining supplements with fertility medications. Many fertility specialists do recommend continuing inositol supplementation alongside ovulation induction medications.

Do I need a diagnosis of PCOS to use Ovulation Support?

No. Conceive Plus Ovulation Support is also beneficial for women with irregular cycles, suspected anovulation, or those who simply want to support regular ovulation — even without a formal PCOS diagnosis.

Does Myo-Inositol cause weight loss?

Myo-Inositol improves insulin sensitivity, which can support healthy weight management as a secondary effect, particularly in women with insulin-resistant PCOS. It is not a weight loss supplement.

Summary

For women with PCOS trying to conceive, Myo-Inositol and D-chiro Inositol at a 40:1 ratio is the most evidence-supported supplement intervention. Conceive Plus Ovulation Support delivers this along with Folate and Vitamin D — formulated specifically to support ovulation regulation in women with PCOS and irregular cycles.

Shop Conceive Plus Ovulation Support